Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 study

Author:

Shah Neil P.1,Guilhot François2,Cortes Jorge E.3,Schiffer Charles A.4,le Coutre Philipp5,Brümmendorf Tim H.6,Kantarjian Hagop M.3,Hochhaus Andreas7,Rousselot Philippe8,Mohamed Hesham9,Healey Diane10,Cunningham Michael10,Saglio Giuseppe11

Affiliation:

1. University of California at San Francisco School of Medicine, San Francisco, CA;

2. INSERM Clinical Investigation Center 1402, Centre Hospitalier et Universitaire de Poitiers, Université de Poitiers, Poitiers, France;

3. The University of Texas MD Anderson Cancer Center, Houston, TX;

4. Karmanos Cancer Institute, Wayne State University, Detroit, MI;

5. Charité, Campus Virchow Klinikum, Universitätsmedizin Berlin, Berlin, Germany;

6. Universitätsklinikum der Rheinisch-Westfälische Technische Hochschule Aachen, Klinik für Hämatologie und Onkologie, Aachen, Germany, and Universitätsklinikum Hamburg-Eppendorf, Klinik für Onkologie und Hämatologie, Hamburg, Germany;

7. Universitätsklinikum Jena, Jena, Germany;

8. Hôpital André Mignot and Université Versailles Saint-Quentin-en-Yvelines, Versailles, France;

9. Bristol-Myers Squibb, Plainsboro, NJ;

10. Bristol-Myers Squibb, Wallingford, CT; and

11. University of Torino, Ospedale San Luigi Gonzaga, Orbassano-Torino, Italy

Abstract

Key Points Imatinib-resistant/-intolerant patients with chronic myeloid leukemia in chronic phase can experience long-term benefit with dasatinib. Early (3- and 6-month) molecular and cytogenetic responses were associated with improved progression-free survival and overall survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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