A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection-Reference-Cited by-同舟云学术

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

Published:2014-07-03 Issue:1 Volume:124 Page:111-120
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Saleh Rosine¹,Wedeh Ghaith¹²,Herrmann Harald³,Bibi Siham¹,Cerny-Reiterer Sabine²³,Sadovnik Irina²,Blatt Katharina²,Hadzijusufovic Emir²³⁴,Jeanningros Sylvie¹,Blanc Catherine⁵,Legarff-Tavernier Magali⁶,Chapiro Elise⁶,Nguyen-Khac Florence⁶,Subra Frédéric¹,Bonnemye Patrick⁶,Dubreuil Patrice⁷⁸⁹¹⁰,Desplat Vanessa¹¹,Merle-Béral Hélène⁶,Willmann Michael⁴,Rülicke Thomas¹²,Valent Peter²³,Arock Michel¹⁶

Affiliation:

1. Laboratoire de Biologie et Pharmacologie Appliquée, Centre Nationale de la Recherche, Unité Mixte de Recherche 8113, Ecole Normale Supérieure de Cachan, Cachan, France;

2. Department of Internal Medicine I, Division of Hematology and Hemostaseology, and

3. Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria;

4. Department of Companion Animals and Horses, Small Animal Clinic, Internal Medicine, University of Veterinary Medicine Vienna, Vienna, Austria;

5. Flow Cytometry Core (Cytometry Pitié-Salpêtrière) CyPS, Université Pierre and Marie Curie, Paris, France;

6. Laboratoire Central d’Hématologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France;

7. Aix-Marseille Université,

8. INSERM U1068, Centre de Recherche en Cancérologie de Marseille, Signaling, Hematopoiesis and Mechanism of Oncogenesis,

9. Institut Paoli-Calmettes, and

10. Centre Nationale de la Recherche Unité Mixte de Recherche 7258, Centre de Recherche en Cancérologie de Marseille, Marseille, France;

11. Laboratoire d’Hématologie, Faculté de Pharmacie, Université Bordeaux Segalen, Bordeaux, France; and

12. Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Vienna, Austria

Abstract

Key Points ROSAKIT WT is a new human SCF-dependent FcεRI-positive mast cell line that converts to SCF-independence by KIT D816V-transfection. The FcεRI-positive ROSAKIT D816V clone is a major tool for studying cellular aspects of mastocytosis and responses to targeted drugs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/1/111/1379642/111.pdf

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4. Human mast cell proteases and mast cell heterogeneity.;Miller;Curr Opin Immunol,1989

5. The human mast cell: functions in physiology and disease.;Krishnaswamy;Front Biosci,2001

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