The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)-Reference-Cited by-同舟云学术

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)

Published:2016-10-06 Issue:14 Volume:128 Page:1789-1799
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Khandelwal Sanjay¹^ORCID,Lee Grace M.¹,Hester C. Garren²,Poncz Mortimer³,McKenzie Steven E.⁴,Sachais Bruce S.⁵,Rauova Lubica³,Kelsoe Garnett⁶,Cines Douglas B.⁷,Frank Michael²⁶,Arepally Gowthami M.¹

Affiliation:

1. Division of Hematology, and

2. Department of Pediatrics, Duke University Medical Center, Durham, NC;

3. Children’s Hospital of Philadelphia, Philadelphia, PA;

4. Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA;

5. New York Blood Center, New York, NY;

6. Department of Immunology, Duke University Medical Center, Durham, NC; and

7. Department of Pathology and Laboratory Medicine, Perelman–University of Pennsylvania School of Medicine, Philadelphia, PA

Abstract

Key Points PF4/heparin ultra-large complexes activate complement and bind preferentially to B cells via CR2 (CD21). Complement-fixed PF4/heparin complexes can be detected on circulating B cells in patients receiving heparin therapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/14/1789/1396216/1789.pdf

Reference36 articles.

1. Determinants of PF4/heparin immunogenicity.;Suvarna;Blood,2007

2. Humoral pattern recognition and the complement system.;Degn;Scand J Immunol,2013

3. Platelet factor 4-heparin complexes trigger immune responses independently of the MyD88 pathway.;Suvarna;Br J Haematol,2008

4. Complexes of platelet factor 4 and heparin activate Toll-like receptor 4.;Prechel;J Thromb Haemost,2015

5. The complement system in regulation of adaptive immunity.;Carroll;Nat Immunol,2004

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