A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults

Author:

Perez-Andreu Virginia1,Roberts Kathryn G.2,Xu Heng13,Smith Colton1,Zhang Hui1,Yang Wenjian1,Harvey Richard C.4,Payne-Turner Debbie2,Devidas Meenakshi5,Cheng I-Ming6,Carroll William L.7,Heerema Nyla A.8,Carroll Andrew J.9,Raetz Elizabeth A.10,Gastier-Foster Julie M.11,Marcucci Guido12,Bloomfield Clara D.12,Mrózek Krzysztof12,Kohlschmidt Jessica1213,Stock Wendy14,Kornblau Steven M.15,Konopleva Marina16,Paietta Elisabeth17,Rowe Jacob M.18,Luger Selina M.19,Tallman Martin S.20,Dean Michael21,Burchard Esteban G.22,Torgerson Dara G.22,Yue Feng23,Wang Yanli23,Pui Ching-Hon24,Jeha Sima24,Relling Mary V.1,Evans William E.1,Gerhard Daniela S.25,Loh Mignon L.26,Willman Cheryl L.6,Hunger Stephen P.27,Mullighan Charles G.2,Yang Jun J.1

Affiliation:

1. Department of Pharmaceutical Sciences and

2. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN;

3. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China;

4. University of New Mexico Cancer Center, Albuquerque, NM;

5. Department of Biostatistics, Colleges of Medicine, Public Health & Health Professions, University of Florida, Gainesville, FL;

6. Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM;

7. Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY;

8. Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH;

9. Department of Genetics, University of Alabama at Birmingham, Birmingham, AL;

10. Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT;

11. The Ohio State University, Nationwide Children’s Hospital, Columbus, OH;

12. Comprehensive Cancer Center, The Ohio State University, Columbus, OH;

13. Alliance of Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester;

14. Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL;

15. Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;

16. The University of Texas MD Anderson Cancer Center, Houston, TX;

17. Department of Medicine (Oncology), Albert Einstein College of Medicine, Yeshiva University, New York, NY;

18. Rambam Medical Center, Haifa, Israel;

19. Hematologic Malignancies Program, Hematology-Oncology Division, University of Pennsylvania, Philadelphia, PA;

20. Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;

21. Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD;

22. Department of Bioengineering & Therapeutic Science and Department of Medicine, University of California, San Francisco, San Francisco, CA;

23. Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA;

24. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN;

25. Office of Cancer Genomics, National Cancer Institute, Bethesda, MD;

26. Department of Pediatrics and the Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, CA; and

27. School of Medicine and Children’s Hospital, University of Colorado School of Medicine, Aurora, CO

Abstract

Key Points In this first ALL GWAS in AYAs, we determined that inherited GATA3 variants strongly influence ALL susceptibility in this age group. These findings revealed similarities and differences in the genetic basis of ALL susceptibility between young children and AYAs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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