Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury

Author:

Tian Ye12,Salsbery Breia2,Wang Min3,Yuan Hengjie12,Yang Jing2,Zhao Zilong1,Wu Xiaoping2,Zhang Yanjun1,Konkle Barbara A.24,Thiagarajan Perumal56,Li Min3,Zhang Jianning1,Dong Jing-fei24

Affiliation:

1. Tianjin Neurological Institute, Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin, China;

2. Puget Sound Blood Research Institute, Seattle, WA;

3. Institute of Pathology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China;

4. Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA;

5. Departments of Pathology and Medicine, Baylor College of Medicine, Houston, TX; and

6. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX

Abstract

Key Points Brain-derived cellular microparticles induce systemic coagulopathy in traumatic brain injury. Platelets facilitate the transmigration of brain microparticles through the endothelial barrier into the circulation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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