Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell–dependent induction of CD4+CD25+FoxP3+ Treg-Reference-Cited by-同舟云学术

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell–dependent induction of CD4+CD25+FoxP3+ Treg

Published:2015-05-07 Issue:19 Volume:125 Page:2937-2947
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Biswas Moanaro¹,Sarkar Debalina¹,Kumar Sandeep R. P.¹,Nayak Sushrusha¹,Rogers Geoffrey L.¹,Markusic David M.¹,Liao Gongxian²,Terhorst Cox²,Herzog Roland W.¹

Affiliation:

1. Department of Pediatrics, University of Florida, Gainesville, FL; and

2. Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA

Abstract

Key Points Rapamycin and Flt3L are synergistic in Treg induction when coadministered with antigen, resulting in improved tolerance induction. pDCs are required for efficient Treg induction and selectively expanded with Flt3L/rapamycin because of high mTOR activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/19/2937/1385343/2937.pdf

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