Leukemia surfaceome analysis reveals new disease-associated features

Author:

Mirkowska Paulina1234,Hofmann Andreas23,Sedek Lukasz5,Slamova Lucie6,Mejstrikova Ester6,Szczepanski Tomasz5,Schmitz Maike134,Cario Gunnar7,Stanulla Martin7,Schrappe Martin7,van der Velden Vincent H. J.8,Bornhauser Beat C.14,Wollscheid Bernd2,Bourquin Jean-Pierre14

Affiliation:

1. Department of Oncology, University Children’s Hospital Zurich, Zurich, Switzerland;

2. Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland;

3. Life Science Zurich Graduate School, Zurich, Switzerland;

4. Children's Research Center, University Children’s Hospital Zurich, Zurich, Switzerland;

5. Department of Pediatric Hematology and Oncology, Zabrze, Medical University of Silesia, Katowice, Poland;

6. Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic;

7. Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany; and

8. Department of Immunology, Erasmus MC, Rotterdam, The Netherlands

Abstract

Key Points Proteomic analysis of the leukemia cell surface reveals new leukemia-associated features with a potential to improve diagnostics. The ALL surfaceome is a resource for systematic functional exploration.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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