Intravenous immunoglobulin expands regulatory T cells via induction of cyclooxygenase-2–dependent prostaglandin E2 in human dendritic cells

Author:

Trinath Jamma12,Hegde Pushpa13,Sharma Meenu13,Maddur Mohan S.145,Rabin Magalie146,Vallat Jean-Michel6,Magy Laurent6,Balaji Kithiganahalli N.2,Kaveri Srini V.1457,Bayry Jagadeesh1457

Affiliation:

1. Unité 872, Institut National de la Santé et de la Recherche Médicale, Paris, France;

2. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India;

3. Université de Technologie de Compiègne, Compiègne, France;

4. Centre de Recherche des Cordeliers, Equipe 16- Immunopathology and therapeutic immunointervention, Université Pierre et Marie Curie, Paris, France;

5. Université Paris Descartes, Paris, France;

6. Centre de Référence ‘Neuropathies Périphériques Rares’ et Service de Neurologie, Hôpital Universitaire Limoges, Limoges, France; and

7. International Associated Laboratory, Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India, National Institute of Immunohaematology, Mumbai, India

Abstract

Key Points IVIg expands Tregs in vitro and in vivo via induction of COX-2–dependent PGE2 in DCs. These functions of IVIg are mediated in part via interaction of IVIg and F(ab′)2 fragments of IVIg with DC-SIGN on DCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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