Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Author:

Bolton-Gillespie Elisabeth1,Schemionek Mirle2,Klein Hans-Ulrich3,Flis Sylwia1,Hoser Grazyna4,Lange Thoralf5,Nieborowska-Skorska Margaret1,Maier Jacqueline5,Kerstiens Linda6,Koptyra Mateusz1,Müller Martin C.7,Modi Hardik8,Stoklosa Tomasz9,Seferynska Ilona10,Bhatia Ravi8,Holyoake Tessa L.11,Koschmieder Steffen2,Skorski Tomasz112

Affiliation:

1. Department of Microbiology and Immunology, School of Medicine, Temple University, Philadelphia, PA;

2. Department of Medicine (Oncology, Hematology, and Stem Cell Transplantation), University Medical Center of Aachen, Aachen, Germany;

3. Institute of Medical Informatics, University of Münster, Münster, Germany;

4. Department of Clinical Cytology, Medical Center for Postgraduate Education, Warsaw, Poland;

5. Abteilung für Hämatologie, Onkologie, Hämostaseologie, Universitätsklinikum Leipzig, Leipzig, Germany;

6. Department of Hematology/Oncology, University of Münster, Münster, Germany;

7. Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany;

8. Division of Hematopoietic Stem Cell and Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA;

9. Department of Immunology, Medical University of Warsaw, Warsaw, Poland;

10. Department of Hematology, Institute of Hematology and Blood Transfusion, Warsaw, Poland;

11. Paul O’Gorman Leukemia Research Centre, University of Glasgow, Glasgow, United Kingdom; and

12. Fels Institute for Cancer Research and Molecular Biology, School of Medicine, Temple University, Philadelphia, PA

Abstract

Key Points Imatinib does not prevent accumulation of genomic instability in CML-CP. Imatinib-refractory leukemia stem cells may be a source of genomic instability in CML-CP.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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