The co-receptor BTLA negatively regulates human Vγ9Vδ2 T-cell proliferation: a potential way of immune escape for lymphoma cells

Author:

Gertner-Dardenne Julie1,Fauriat Cyril1,Orlanducci Florence2,Thibult Marie-Laure1,Pastor Sonia1,Fitzgibbon Jude3,Bouabdallah Reda4,Xerri Luc124,Olive Daniel124

Affiliation:

1. Institut National de la Santé Et de la Recherche Scientifique, U1068, Centre de Recherche en Cancérologie de Marseille, Immunity & Cancer, Marseille, France;

2. Institut Paoli Calmettes, Marseille, France;

3. Barts Cancer Institute, Cancer Research UK Centre of Excellence, John Vane Science Centre, Queen Mary University of London, London, United Kingdom; and

4. Aix-Marseille University, Marseille, France

Abstract

Key Points BTLA-HVEM interaction negatively regulates the proliferation of LTγδ. BTLA-HVEM interaction appears as a new possible mechanism of immune escape by lymphoma cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference51 articles.

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