The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents-Reference-Cited by-同舟云学术

The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents

Published:2013-09-12 Issue:11 Volume:122 Page:1900-1913
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dos Santos Cedric¹,McDonald Tinisha¹,Ho Yin Wei¹,Liu Hongjun¹,Lin Allen¹,Forman Stephen J.²,Kuo Ya-Huei¹,Bhatia Ravi¹

Affiliation:

1. Division of Hematopoietic Stem Cell and Leukemia Research and

2. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA

Abstract

Key Points SRC family kinases are activated in AML stem/progenitor cells and contribute to AML stem cell survival and proliferation. Combined inhibition of SFKs and c-KIT with dasatinib enhances p53-mediated elimination of AML stem cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/11/1900/1331469/1900.pdf

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