Reperfusion of cerebral artery thrombosis by the GPIb–VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs-Reference-Cited by-同舟云学术

Reperfusion of cerebral artery thrombosis by the GPIb–VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs

Published:2013-06-20 Issue:25 Volume:121 Page:5088-5097
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Momi Stefania¹,Tantucci Michela²,Van Roy Maarten³,Ulrichts Hans³,Ricci Giovanni⁴,Gresele Paolo¹

Affiliation:

1. Section of Internal and Cardiovascular Medicine, Department of Internal Medicine,

2. Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy;

3. Ablynx, Zwijnaarde, Belgium; and

4. Histology Section, Animal Facility, University of Perugia, Perugia, Italy

Abstract

Key Points Blockade of VWF-A1 by ALX-0081 induces reperfusion of a thrombus-occluded middle cerebral artery without provoking cerebral bleeding. The interaction between GPIb and VWF is not only essential for platelet adhesion but also for initial thrombus stabilization.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/25/5088/1366745/5088.pdf

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