Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l-Reference-Cited by-同舟云学术

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

Published:2013-03-28 Issue:13 Volume:121 Page:2533-2541
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Deshpande Aniruddha J.¹²³,Chen Liying¹²⁴,Fazio Maurizio¹⁵,Sinha Amit U.¹²³,Bernt Kathrin M.¹²⁶,Banka Deepti¹²,Dias Stuart¹²,Chang Jenny¹²³,Olhava Edward J.⁷,Daigle Scott R.⁷,Richon Victoria M.⁷,Pollock Roy M.⁷,Armstrong Scott A.¹²³⁸

Affiliation:

1. Division of Hematology/Oncology, Children's Hospital,

2. Department of Pediatric Oncology and Harvard Medical School, Boston, MA;

3. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY;

4. Department of Molecular and Cellular Biology, Harvard University, Boston, MA;

5. Functional Genomics of Cancer Unit, Scientific Institute S. Raffaele, Milan, Italy;

6. Department of Pediatrics, University of Colorado Anshutz Medical Campus, Aurora, CO;

7. Epizyme Inc, Cambridge, MA; and

8. Harvard Stem Cell Institute, Boston, MA

Abstract

Key Points Our study demonstrates aberrant genome-wide deposition of histone 3 lysine 79 dimethylation on MLL-target genes in MLL-AF6–driven leukemia cells. We provide evidence that leukemia cells bearing the MLL-AF6 fusion are sensitive to genetic and pharmacologic DOT1L inhibition.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/13/2533/1365467/2533.pdf

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