Specific gene delivery to liver sinusoidal and artery endothelial cells

Author:

Abel Tobias1,El Filali Ebtisam2,Waern Johan3,Schneider Irene C.1,Yuan Qinggong3,Münch Robert C.1,Hick Meike4,Warnecke Gregor5,Madrahimov Nodir5,Kontermann Roland E.6,Schüttrumpf Jörg7,Müller Ulrike C.4,Seppen Jurgen2,Ott Michael3,Buchholz Christian J.1

Affiliation:

1. Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany;

2. Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;

3. Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, and Twincore Institute for Experimental and Clinical Infection Research, Hannover, Germany;

4. Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany;

5. Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany;

6. Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany; and

7. Institute for Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany

Abstract

Key Points CD105-mediated cell entry using targeted lentiviral vectors leads to specific gene transfer of LSEC upon systemic administration.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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