Disruption of a GATA1-binding motif upstream of XG/PBDX abolishes Xga expression and resolves the Xg blood group system-Reference-Cited by-同舟云学术

Disruption of a GATA1-binding motif upstream of XG/PBDX abolishes Xga expression and resolves the Xg blood group system

Published:2018-07-19 Issue:3 Volume:132 Page:334-338
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Möller Mattias¹^ORCID,Lee Yan Quan¹^ORCID,Vidovic Karina¹^ORCID,Kjellström Sven²³^ORCID,Björkman Linda⁴,Storry Jill R.¹⁴^ORCID,Olsson Martin L.¹⁴^ORCID

Affiliation:

1. Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine,

2. Department of Clinical Sciences Lund, and

3. Center of Excellence in Biological and Medical Mass Spectrometry, Lund University, Lund, Sweden; and

4. Department of Clinical Immunology and Transfusion Medicine, Office of Medical Services, Lund, Sweden

Abstract

Key Points Expression of the Xg blood group protein is governed by rs311103, and its minor allele disrupts a GATA motif to cause the Xg(a−) phenotype. These data elucidate the genetic basis of the last unresolved blood group system and make genotyping for Xga status possible.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/3/334/1372208/blood842542.pdf

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