von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury

Author:

Wu Yingang123,Liu Wei45,Zhou Yuan12,Hilton Tristan3,Zhao Zilong12,Liu Wei26,Wang Min45,Yeon Jason3,Houck Katie3,Thiagarajan Perumal789,Zhang Fangyi10,Shi Fu-Dong1112,Wu Xiaoping4,Li Min56,Dong Jing-fei412,Zhang Jianning123

Affiliation:

1. Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin, China;

2. Tianjin Medical University General Hospital, Tianjin, China;

3. Bloodworks Research Institute, Seattle, WA;

4. Institute of Pathology, School of Medical Sciences, and

5. Gansu Provincial Key Laboratory of Preclinical Study for New Drug Development, Lanzhou University, Lanzhou, China;

6. Department of Neurology, Tianjin Institute of Neurology, Tianjin, China;

7. Department of Medicine and

8. Department of Pathology, Baylor College of Medicine, Houston, TX;

9. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX;

10. Department of Neurosurgery, University of Washington School of Medicine, Seattle, WA;

11. Department of Neurology, Barrow Neurological Institute, St. Joseph’s Hospital, Phoenix, AZ; and

12. Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA

Abstract

Key Points Injured brain releases hyperadhesive and microvesicle-bound VWF that causes neurological dysfunction and a systemic hypercoagulable state. ADAMTS-13 protected the blood-brain barrier to prevent TBI-induced neurological dysfunction and systemic coagulopathy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference35 articles.

1. Biochemistry and genetics of von Willebrand factor;Sadler

2. Topology and order of formation of interchain disulfide bonds in von Willebrand factor;Wagner;Blood,1987

3. von Willebrand factor proteolytic processing and multimerization precede the formation of Weibel-Palade bodies;Vischer;Blood,1994

4. In vitro multimerization of von Willebrand factor is triggered by low pH. Importance of the propolypeptide and free sulfhydryls;Mayadas;J Biol Chem,1989

5. Inducible secretion of large, biologically potent von Willebrand factor multimers;Sporn;Cell,1986

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