RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia
Author:
Affiliation:
1. Division of Pharmaceutics, College of Pharmacy,
2. Comprehensive Cancer Center,
3. Division of Hematology-Oncology, and
4. Department of Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, OH
Abstract
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/119/22/5229/1492812/zh802212005229.pdf
Reference47 articles.
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3. Microbiological production of 5-azacytidine. I. Production and biological activity.;Hanka;Antimicrob Agents Chemother (Bethesda),1966
4. 5-azacytidine and decitabine monotherapies of myelodysplastic disorders.;Kuykendall;Ann Pharmacother,2005
5. Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity.;Murakami;Cancer Res,1995
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