Point/counterpoint: early-stage Hodgkin lymphoma and the role of radiation therapy

Author:

Meyer Ralph M.1234,Hoppe Richard T.5

Affiliation:

1. National Cancer Institute of Canada (NCIC) Clinical Trials Group and

2. the Departments of Oncology,

3. Medicine, and

4. Community Health and Epidemiology, Queen's University, Kingston, ON; and

5. Department of Radiation Oncology, Stanford University, Stanford, CA

Abstract

Abstract The results of recent clinical trials for the management of limited-stage Hodgkin lymphoma have led to considerable debate, especially regarding the role of radiation therapy. This review highlights those recent trials and provides perspectives regarding their interpretation from a radiation oncologist and a hematologist. The trial protocol is available at http://www.nejm.org/doi/suppl/10.1056/NEJMoa1111961/suppl_file/nejmoa1111961_protocol.pdf.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference57 articles.

1. Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.;Engert;N Engl J Med,2010

2. ABVD alone versus radiation-based therapy in limited-stage Hodgkin's lymphoma.;Meyer;N Engl J Med,2012

3. Hodgkin lymphoma.;Hoppe;J Natl Compr Canc Netw,2011

4. Cases of sarcoma and of Hodgkin's disease treated by exposure to X-rays: a preliminary report.;Pusey;JAMA,1902

5. Notre Methode De Roentgentherapie De La Lymphogranulomatose (Hodgkin): Resultats Eloignes.;Gilbert;Acta Radiol,1931

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