Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factors

Author:

Cohen Kenneth S.12,Cheng Susan345,Larson Martin G.46,Cupples L. Adrienne7,McCabe Elizabeth L.3,Wang Ying A.7,Ngwa Julius S.7,Martin Roderick P.18,Klein Rachael J.1,Hashmi Basma9,Ge Yin10,O'Donnell Christopher J.3411,Vasan Ramachandran S.412,Shaw Stanley Y.313,Wang Thomas J.34

Affiliation:

1. Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

2. Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL;

3. Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

4. Framingham Heart Study, Framingham, MA;

5. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;

6. Department of Mathematics and Statistics, Boston University, Boston, MA;

7. Department of Biostatistics, Boston University School of Public Health, Boston, MA;

8. Genzyme Corporation, Cambridge, MA;

9. Bioengineering Department, Harvard University, Boston, MA;

10. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA;

11. Center for Population Studies, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

12. Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, Boston, MA; and

13. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Abstract

Key Points CD34+ progenitor cell frequency is reduced in older subjects, and is influenced by environmental factors such as smoking and statin use. CD34+ progenitor cell frequency is highly heritable and associated with common genetic variants at several loci.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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