Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling-Reference-Cited by-同舟云学术

Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling

Published:2006-07-01 Issue:1 Volume:108 Page:305-310
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Campese Antonio F.¹,Garbe Annette I.¹,Zhang Fangrong¹,Grassi Fabio¹,Screpanti Isabella¹,von Boehmer Harald¹

Affiliation:

1. From Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA; the Department of Experimental Medicine and Pathology, University “La Sapienza,” Rome, Italy; and the Institute for Research in Biomedicine, Bellinzona, Switzerland.

Abstract

Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2-/- mice by transient mimicking of pre-TCR signals. (Blood. 2006;108:305-310)

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/108/1/305/470283/zh801306000305.pdf

Reference21 articles.

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