FVIIa as used pharmacologically is not TF dependent in hemophilia B mice-Reference-Cited by-同舟云学术

FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

Published:2014-03-13 Issue:11 Volume:123 Page:1764-1766
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Feng Dengmin¹,Whinna Herbert²,Monroe Dougald³,Stafford Darrel W.¹

Affiliation:

1. Department of Biology,

2. Department of Pathology, and

3. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

Abstract

Key Points A chimeric molecule that does not bind TF is as effective as FVIIa in preventing bleeding. An in vivo model of TF dependence of FVIIa supports the phospholipid-binding model.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/11/1764/537474/1764.pdf

Reference20 articles.

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3. High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system.;Kjalke;Br J Haematol,2001

4. Further understanding of recombinant activated factor VII mode of action.;Monroe;Semin Hematol,2008

5. The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface.;Weeterings;Blood,2008

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