Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin-Reference-Cited by-同舟云学术

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin

Published:2014-03-06 Issue:10 Volume:123 Page:1596-1603
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cines Douglas B.¹,Lebedeva Tatiana¹,Nagaswami Chandrasekaran²,Hayes Vincent³,Massefski Walter⁴,Litvinov Rustem I.²,Rauova Lubica³⁵,Lowery Thomas J.⁴,Weisel John W.²

Affiliation:

1. Department of Pathology and Laboratory Medicine and

2. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

3. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA;

4. T2 Biosystems, Lexington, MA; and

5. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Abstract

Key PointsIn contracted clots and thrombi, erythrocytes are compressed to close-packed polyhedral structures with platelets and fibrin on the surface. Polyhedrocytes form an impermeable seal to stem bleeding and help prevent vascular obstruction but confer resistance to fibrinolysis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/10/1596/1374269/1596.pdf

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3. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease.;Lane;Blood,2000

4. The structural properties and contractile force of a clot.;Jen;Cell Motil,1982

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