Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion-Reference-Cited by-同舟云学术

Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion

Published:2014-02-27 Issue:9 Volume:123 Page:1412-1421
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bachireddy Pavan¹²³,Hainz Ursula²,Rooney Michael⁴,Pozdnyakova Olga⁵,Aldridge Julie⁶,Zhang Wandi²,Liao Xiaoyun¹⁷,Hodi F. Stephen¹⁷⁸,O’Connell Karyn²,Haining W. Nicholas⁹,Goldstein Natalie R.¹,Canning Christine M.¹²,Soiffer Robert J.¹³,Ritz Jerome¹²³,Hacohen Nir⁴¹⁰,Alyea Edwin P.¹³,Kim Haesook T.⁶,Wu Catherine J.¹²³

Affiliation:

1. Department of Medical Oncology and

2. Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA;

3. Department of Medicine, Brigham & Women's Hospital, Boston, MA;

4. Broad Institute of MIT and Harvard, Cambridge, MA;

5. Department of Pathology, Brigham & Women's Hospital, Boston, MA;

6. Division of Biostatistics & Computational Biology,

7. Center for Immuno-Oncology,

8. Melanoma Disease Center, and

9. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA; and

10. Division of Immunology and Rheumatology, Department of Medicine, Massachusetts General Hospital, Boston, MA

Abstract

Key Points Marrow CD8+ T-cell infiltrates may be a novel predictor of response to donor lymphocyte infusions in patients with relapsed CML. Reversal of T-cell exhaustion is tightly linked to effective antileukemia responses to donor lymphocyte infusions.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/9/1412/1379303/1412.pdf

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