Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice-Reference-Cited by-同舟云学术

Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice

Published:2014-06-12 Issue:24 Volume:123 Page:3760-3769
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Komeno Yukiko¹,Yan Ming¹,Matsuura Shinobu¹,Lam Kentson²,Lo Miao-Chia¹,Huang Yi-Jou³,Tenen Daniel G.⁴,Downing James R.⁵,Zhang Dong-Er¹²³⁶

Affiliation:

1. Moores University California San Diego Cancer Center,

2. Biomedical Science Graduate Program, and

3. Division of Biological Sciences, University of California San Diego, La Jolla, CA;

4. Harvard Stem Cell Institute, Harvard Medical School, Boston, MA;

5. Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN; and

6. Department of Pathology, University of California San Diego, La Jolla, CA

Abstract

Key Points Human RUNX1a orthologs are only found in primates. Alternative splicing of Runx1 involving exon 6 affects the pool size of hematopoietic stem cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/24/3760/1377922/3760.pdf

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5. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.;Huang;Nat Genet,2008

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