Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct-Reference-Cited by-同舟云学术

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

Published:2014-05-15 Issue:20 Volume:123 Page:e110-e122
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gundra Uma Mahesh¹,Girgis Natasha M.¹,Ruckerl Dominik²,Jenkins Stephen²,Ward Lauren N.¹,Kurtz Zachary D.¹,Wiens Kirsten E.¹,Tang Mei San¹,Basu-Roy Upal¹,Mansukhani Alka¹,Allen Judith E.²^ORCID,Loke P’ng¹

Affiliation:

1. Department of Microbiology, New York University School of Medicine, New York, NY; and

2. Centre for Immunity, Infection and Evolution, and the Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

Abstract

Key Points Alternatively activated macrophages derived from monocytes and tissue macrophages have distinct transcriptional profiles and phenotypes. Monocyte-derived AAMs are more involved with immune regulation than tissue-derived AAMs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/20/e110/1376869/e110.pdf

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4. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages.;Hoeffel;J Exp Med,2012

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