Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice-Reference-Cited by-同舟云学术

Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice

Published:2014-05-08 Issue:19 Volume:123 Page:3045-3055
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Newman Robert G.¹²,Dee Michael J.²,Malek Thomas R.²,Podack Eckhard R.²,Levy Robert B.²^ORCID

Affiliation:

1. Sheila and David Fuente Graduate Program in Cancer Biology, Sylvester Comprehensive Cancer Center, Miami, FL; and

2. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL

Abstract

Key PointsVaccination with lymphoma cells secreting gp96-Ig together with directed IL-2 rapidly elicit effective tumor immunity after syngeneic HSCT. IL-2 cytokine-antibody complex expands CD8+ T lymphocytes and NK cells and enhances pathogen immunity early after HSCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/19/3045/1376665/3045.pdf

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