Efficacy of Pirtobrutinib in Covalent BTK-Inhibitor Pre-Treated Relapsed / Refractory Mantle Cell Lymphoma: Additional Patients and Extended Follow-up from the Phase 1/2 BRUIN Study

Author:

Wang Michael L.1,Shah Nirav N.2,Jurczak Wojciech3,Zinzani Pier Luigi4,Eyre Toby A.5,Cheah Chan Y.6,Ujjani Chaitra S.7,Koh Youngil8,Izutsu Koji9,Gerson James N.10,Flinn Ian W.11,Tessoulin Benoit12,Alencar Alvaro J.13,Ma Shuo14,Lech-Marańda Ewa15,Rhodes Joanna M.16,Patel Krish17,Woyach Jennifer A.18,Lamanna Nicole19,Wang Yucai20,Tam Constantine S.21,Seymour John F.21,Munir Talha22,Nagai Hirokazu23,Hernandez-Ilizaliturri Francisco24,Kumar Anita25,Zelenetz Andrew D.25,Jain Preetesh26,Nair Binoj27,Tsai Donald E.27,Balbas Minna27,Walgren Richard A.27,Abada Paolo B.27,Wang Chunxiao28,Zhao Junjie27,Mato Anthony R.25

Affiliation:

1. 1MD Anderson Cancer Center, Houston, TX

2. 2Medical College of Wisconsin, Brookfield, WI

3. 3Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland

4. 4Institute of Hematology "Seràgnoli", University of Bologna, Bologna, Italy

5. 5Oxford University Hospitals NHS Foundation Trust, Churchill Cancer Center, Oxford, United Kingdom

6. 6Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia

7. 7Fred Hutchinson Cancer Center, University of Washington, Seattle, WA

8. 8Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)

9. 9National Cancer Center Hospital, Tokyo, Japan

10. 10Lymphoma Program, Abramson Cancer Center, Philadelphia, PA

11. 11Sarah Cannon Research Institute, Nashville, TN

12. 12Hematology Department, Nantes University Hospital, Nantes, France

13. 13Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL

14. 14Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL

15. 15Institute of Hematology and Transfusion Medicine, Warsaw, Poland

16. 16Northwell Health Cancer Institute, New Hyde Park, NY

17. 17Swedish Cancer Institute, Center for Blood Disorders and Cellular Therapy, Seattle, WA

18. 18The Ohio State University Comprehensive Cancer Center, Columbus, OH

19. 19New York-Presbyterian/ Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, New York, NY

20. 20Division of Hematology, Mayo Clinic, Rochester, MN

21. 21Peter MacCallum Cancer Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia

22. 22Department of Haematology, St James's University Hospital, Leeds, United Kingdom

23. 23Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

24. 24Roswell Park Cancer Institute, Buffalo, NY

25. 25Memorial Sloan Kettering Cancer Center, New York, NY

26. 26Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX

27. 27Loxo@Lilly, Indianapolis, IN

28. 28Eli Lilly and Company, Indianapolis, IN

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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