Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma

Author:

Weilemann Andre1234,Grau Michael5,Erdmann Tabea123,Merkel Olaf6,Sobhiafshar Ulduz7,Anagnostopoulos Ioannis8,Hummel Michael8,Siegert Antje9,Hayford Claudia2,Madle Hannelore123,Wollert-Wulf Brigitte210,Fichtner Iduna9,Dörken Bernd210,Dirnhofer Stephan11,Mathas Stephan210,Janz Martin210,Emre N. C. Tolga7,Rosenwald Andreas12,Ott German13,Lenz Peter5,Tzankov Alexandar11,Lenz Georg123

Affiliation:

1. Department of Medicine A, Translational Oncology, Albert-Schweitzer Campus 1, University Hospital Münster, Münster, Germany;

2. Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany;

3. Cells in Motion Cluster of Excellence, Münster, Germany;

4. Mathematisch-Naturwissenschaftliche Fakultät I, Humboldt University Berlin, Berlin, Germany;

5. Department of Physics, Philipps-University, Marburg, Germany;

6. Department of Experimental Pathology, Medical University Vienna, Wien, Austria;

7. Department of Molecular Biology and Genetics, Boğaziçi University, Bebek, Istanbul, Turkey;

8. Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany;

9. Experimental Pharmacology & Oncology Berlin-Buch GmbH, Berlin, Germany;

10. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany;

11. Institute of Pathology, University Hospital, Basel, Switzerland;

12. Department of Pathology, University of Würzburg, Würzburg, Germany; and

13. Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany

Abstract

Key Points IRF4 regulates MYC expression in ALCL. ALCL survival depends on IRF4/MYC signaling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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