Central nervous system acute lymphoblastic leukemia: role of natural killer cells

Author:

Frishman-Levy Liron12,Shemesh Avishai3,Bar-Sinai Allan4,Ma Chao5,Ni Zhenya5,Frenkel Shahar6,Muench Vera7,Bruckmueller Hilke8,Vokuhl Christian9,Debatin Klaus-Michael7,Eckert Cornelia10,Stanulla Martin11,Schrappe Martin8,Campbell Kerry S.12,Loewenthal Ron13,Schewe Denis M.8,Hochman Jacob4,Meyer Lueder H.7,Kaufman Dan5,Cario Gunnar8,Porgador Angel3,Izraeli Shai12

Affiliation:

1. Childhood Leukemia Research Section, Department of Pediatric Oncology and the Cancer Research Center, Edmond and Lily Safra Children Hospital and Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;

2. Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel;

3. The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences and The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel;

4. Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel;

5. Department of Medicine and Stem Cell Institute, University of Minnesota, Minneapolis, MN;

6. Ocular Oncology Service, Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;

7. Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany;

8. Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany;

9. Department of Pediatric Pathology, University Hospital Schleswig Hostein, Kiel, Germany;

10. Department of Pediatric Oncology/Hematology, Charité Universitäts Medizin Berlin, Berlin, Germany;

11. Department of Pediatric Oncology, Hannover Medical School, Hannover, Germany;

12. The Research Institute of Fox Chase Cancer Center, Philadelphia, PA; and

13. Tissue Typing Laboratory and National Laboratory for Solid Organ Transplants, Sheba Medical Center, Ramat Gan, Israel

Abstract

Key Points Increased IL-15 expression in leukemic lymphoblasts is associated with activation of NK cells. The CNS may be an immunologic sanctuary protecting lymphoblasts from NK-cell activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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