A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia-Reference-Cited by-同舟云学术

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia

Published:2015-04-02 Issue:14 Volume:125 Page:2265-2275
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Guida Claudia¹²,Altamura Sandro¹³,Klein Felix A.²,Galy Bruno²,Boutros Michael⁴,Ulmer Artur J.⁵,Hentze Matthias W.²³,Muckenthaler Martina U.¹³

Affiliation:

1. Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany;

2. European Molecular Biology Laboratory, Heidelberg, Germany;

3. Molecular Medicine Partnership Unit, Heidelberg, Germany;

4. Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany; and

5. Department of Immunology and Cell Biology, Research Centre Borstel, Borstel, Germany

Abstract

Key PointsStimulation of Toll-like receptors 2 and 6 reduces ferroportin expression in mouse macrophages by hepcidin-independent mechanism(s). Reduced expression of ferroportin in macrophages that recycle iron from red cells is sufficient to rapidly induce hypoferremia in mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/14/2265/1384531/2265.pdf

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