DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features

Author:

Arribas Alberto J.1,Rinaldi Andrea1,Mensah Afua A.1,Kwee Ivo12,Cascione Luciano13ORCID,Robles Eloy F.4,Martinez-Climent Jose A.4,Oscier David5,Arcaini Luca6,Baldini Luca7,Marasca Roberto8,Thieblemont Catherine9,Briere Josette9,Forconi Francesco1011,Zamò Alberto12,Bonifacio Massimiliano12,Mollejo Manuela13,Facchetti Fabio14,Dirnhofer Stephan15,Ponzoni Maurilio16,Bhagat Govind17,Piris Miguel A.18,Gaidano Gianluca19,Zucca Emanuele3,Rossi Davide19,Bertoni Francesco13ORCID

Affiliation:

1. Lymphoma & Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland;

2. Dalle Molle Institute for Artificial Intelligence, Manno, Switzerland;

3. Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;

4. Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain;

5. Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom;

6. Division of Hematology, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, University of Pavia, Pavia, Italy;

7. Hematology/Bone Marrow Transplantation Unit, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Ca’Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy;

8. Division of Hematology, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy;

9. Hematology Laboratory and Service d’Hemato-oncologie, Hopitaé Saint-Louis, Université Paris Diderot, Paris, France;

10. Haematology Oncology Group, Cancer Sciences Unit, Cancer Research UK Centre, University of Southampton and Haematology Department, Southampton University Hospital Trust, Southampton, United Kingdom;

11. Division of Haematology, University of Siena, Siena, Italy;

12. Departments of Pathology and Hematology, University of Verona, Verona, Italy;

13. Department of Pathology, Hospital Virgen de la Salud, Toledo, Spain;

14. Department of Pathology, University of Brescia, I Servizio di Anatomia Patologica, Spedali Civili di Brescia, Brescia, Italy;

15. Institute of Pathology, University of Basel, Basel, Switzerland;

16. Pathology Unit and Unit of Lymphoid Malignancies, San Raffaele H Scientific Institute, Milan, Italy;

17. Herbert Irving Comprehensive Cancer Center, Department of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY;

18. Department of Pathology, Hospital Marques de Valdecilla, Santander, Spain; and

19. Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy

Abstract

Key Points Methylation profiling identifies subgroups of SMZL with distinct biological features. Demethylating agents can reverse some of the adverse epigenetic alterations.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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