Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale-Reference-Cited by-同舟云学术

Comparative analysis of human ex vivo–generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale

Published:2015-06-04 Issue:23 Volume:125 Page:3627-3636
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Yuhuan¹,Hayes Vincent¹,Jarocha Danuta¹²,Sim Xiuli¹³,Harper Dawn C.⁴,Fuentes Rudy¹,Sullivan Spencer K.¹,Gadue Paul¹³,Chou Stella T.¹³,Torok-Storb Beverly J.⁵,Marks Michael S.³⁴,French Deborah L.¹³,Poncz Mortimer¹³

Affiliation:

1. Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA;

2. Department of Transplantation, Jagiellonian University, Medical College, Cracow, Poland;

3. Departments of Pediatrics and Pathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

4. Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA; and

5. Fred Hutchinson Cancer Research Center, Seattle, WA

Abstract

Key Points Infused human megakaryocytes release young platelets in the lungs with characteristics similar to donor platelets. Platelets released from ex vivo–derived megakaryocytes are preactivated and compare poorly to donor platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/23/3627/1388057/3627.pdf

Reference55 articles.

1. Platelet function beyond hemostasis and thrombosis.;Ware;Curr Opin Hematol,2013

2. Platelets as cellular effectors of inflammation in vascular diseases.;Rondina;Circ Res,2013

3. How platelets safeguard vascular integrity.;Ho-Tin-Noé;J Thromb Haemost,2011

4. Platelets in lung biology.;Weyrich;Annu Rev Physiol,2013

5. The incredible journey: From megakaryocyte development to platelet formation.;Machlus;J Cell Biol,2013

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