Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

Author:

Meinders Marjolein1,Kulu Divine I.2,van de Werken Harmen J. G.2,Hoogenboezem Mark3,Janssen Hans4,Brouwer Rutger W. W.5,van Ijcken Wilfred F. J.5,Rijkers Erik-Jan6,Demmers Jeroen A. A.6,Krüger Imme7,van den Berg Timo K.1,Suske Guntram7,Gutiérrez Laura1ORCID,Philipsen Sjaak2

Affiliation:

1. Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;

2. Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands;

3. Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;

4. Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;

5. Center for Biomics, and

6. Proteomics Center, Erasmus MC, Rotterdam, The Netherlands; and

7. Institute of Molecular Biology and Tumor Research, Philipps-University Marburg, Marburg, Germany

Abstract

Key Points Megakaryocyte-specific Sp1/Sp3 double-knockout mice display thrombocytopenia, platelet dysfunction, and defects in megakaryocyte maturation. Selective Mylk inhibition by ML7 affects proplatelet formation and stabilization and ITAM receptor–mediated platelet aggregation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference78 articles.

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2. Megakaryopoiesis.;Geddis;Semin Hematol,2010

3. Unraveling mechanisms that control platelet production.;Italiano;Semin Thromb Hemost,2013

4. Of mice and men: comparison of the ultrastructure of megakaryocytes and platelets.;Schmitt;Exp Hematol,2001

5. The physiology of platelet production.;Kuter;Stem Cells,1996

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