β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome

Author:

Tanimura Kenji12,Jin Hui13,Suenaga Tadahiro13,Morikami Satoko23,Arase Noriko14,Kishida Kazuki13,Hirayasu Kouyuki3,Kohyama Masako13,Ebina Yasuhiko2,Yasuda Shinsuke5,Horita Tetsuya5,Takasugi Kiyoshi6,Ohmura Koichiro7,Yamamoto Ken8,Katayama Ichiro4,Sasazuki Takehiko9,Lanier Lewis L.10,Atsumi Tatsuya5,Yamada Hideto2,Arase Hisashi1311ORCID

Affiliation:

1. Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan;

2. Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan;

3. Laboratory of Immunochemistry, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan;

4. Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;

5. Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan;

6. Department of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyma, Ehime, Japan;

7. Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan;

8. Division of Genome Analysis, Medical Institute of Bioregulation, and

9. Institute for Advanced Study, Kyushu University, Fukuoka, Fukuoka, Japan;

10. Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA; and

11. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Honcho Kawaguchi, Saitama, Japan

Abstract

Key Pointsβ2GPI complexed with HLA class II molecules was found to be a target for autoantibodies in APS. More than 80% of patients with APS possess autoantibodies against β2GPI/HLA class II complexes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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