Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies-Reference-Cited by-同舟云学术

Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies

Published:2015-04-02 Issue:14 Volume:125 Page:2254-2264
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Di Buduo Christian A.¹²,Wray Lindsay S.¹²³,Tozzi Lorenzo¹²³,Malara Alessandro¹²,Chen Ying³,Ghezzi Chiara E.³,Smoot Daniel³,Sfara Carla⁴,Antonelli Antonella⁴,Spedden Elise⁵,Bruni Giovanna⁶,Staii Cristian⁵,De Marco Luigi⁷⁸,Magnani Mauro⁴,Kaplan David L.³,Balduini Alessandra¹²³

Affiliation:

1. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

2. Biotechnology Research Laboratories, Istituto di Ricovero e Cura a Carattere Scientifico San Matteo Foundation, Pavia, Italy;

3. Department of Biomedical Engineering, Tufts University, Medford, MA;

4. Department of Biomolecular Sciences, Biochemistry and Molecular Biology Section, University of Urbino “Carlo Bo,” Urbino, Italy;

5. Department of Physics, Tufts University, Medford, MA;

6. Department of Chemistry, Physical Chemistry Section, University of Pavia, Pavia, Italy;

7. Department of Translational Research, Stem Cells Unit, Istituto di Ricovero e Cura a Carattere Scientifico Centro di Riferimento Oncologico, Aviano, Italy; and

8. Department of Molecular and Experimental Research, The Scripps Research Institute, La Jolla, CA

Abstract

Key Points Natural silk protein sponge and vascular tubes reproduce human bone marrow niche environments for functional platelet generation ex vivo. Programmable bioengineered model for the investigation and therapeutic targeting of altered platelet formation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/14/2254/1384193/2254.pdf

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