Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets-Reference-Cited by-同舟云学术

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Published:2016-04-07 Issue:14 Volume:127 Page:1743-1751
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rowley Jesse W.¹²,Chappaz Stéphane³,Corduan Aurélie⁴,Chong Mark M. W.³,Campbell Robert¹²,Khoury Amanda¹,Manne Bhanu Kanth¹,Wurtzel Jeremy G. T.⁵⁶,Michael James V.⁵⁶,Goldfinger Lawrence E.⁵⁶,Mumaw Michele M.⁷,Nieman Marvin T.⁷,Kile Benjamin T.³,Provost Patrick⁴^ORCID,Weyrich Andrew S.¹²

Affiliation:

1. The Molecular Medicine Program and

2. Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT;

3. Australian Cancer Research Foundation Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;

4. Centre Hospitalier Universitaire de Québec Research Center and Faculty of Medicine, Université Laval, Québec, QC, Canada;

5. Department of Anatomy and Cell Biology and The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA;

6. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA; and

7. Deparment of Pharmacology, Case Western Reserve University, Cleveland, OH

Abstract

Key Points Dicer1 deletion in MKs alters platelet miRNA and mRNA profiles. Dicer1-deficient platelets display increased integrins αIIb and β3 levels and enhanced in vitro and in vivo functional responses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/14/1743/1392616/1743.pdf

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