Structural basis for PECAM-1 homophilic binding-Reference-Cited by-同舟云学术

Structural basis for PECAM-1 homophilic binding

Published:2016-02-25 Issue:8 Volume:127 Page:1052-1061
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Paddock Cathy¹,Zhou Dongwen¹,Lertkiatmongkol Panida¹²,Newman Peter J.¹²,Zhu Jieqing¹³

Affiliation:

1. Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI; and

2. Department of Pharmacology and

3. Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI

Abstract

Key Points PECAM-1 is enriched at endothelial cell intercellular junctions, where it regulates leukocyte trafficking and vascular permeability. An atomic-level model of junctional PECAM-1 has been built based on a 2.8-Å resolution structure of its homophilic-binding domain.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/8/1052/1394907/1052.pdf

Reference74 articles.

1. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.;Newman;Science,1990

2. A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions.;Muller;J Exp Med,1989

3. EndoCAM: a novel endothelial cell-cell adhesion molecule.;Albelda;J Cell Biol,1990

4. Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.;Vonderheide;J Cell Biol,1994

5. The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.;Wang;Proc Natl Acad Sci USA,1995

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