AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model-Reference-Cited by-同舟云学术

AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model

Published:2013-03-21 Issue:12 Volume:121 Page:e90-e97
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wunderlich Mark¹,Mizukawa Benjamin¹²,Chou Fu-Sheng¹,Sexton Christina¹,Shrestha Mahesh¹,Saunthararajah Yogen³,Mulloy James C.¹

Affiliation:

1. Divisions of Experimental Hematology and Cancer Biology, and

2. Oncology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH; and

3. Departments of Translational Hematology and Oncology Research, and Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Abstract

Key Points A relevant xenograft chemotherapy model was developed by using standard AML induction therapy drugs and primary human AML patient samples. Human AML cells show significantly increased sensitivity to in vivo chemotherapy treatment compared with murine LSK and total bone marrow cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/12/e90/1364840/e90.pdf

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