Fev regulates hematopoietic stem cell development via ERK signaling

Author:

Wang Lu1,Liu Tianhui2,Xu Linjie3,Gao Ya1,Wei Yonglong1,Duan Caiwen2,Chen Guo-Qiang2,Lin Shuo4,Patient Roger5,Zhang Bo3,Hong Dengli2,Liu Feng1

Affiliation:

1. State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;

2. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiaotong University School of Medicine, Shanghai, China;

3. Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Beijing, China;

4. Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA; and

5. Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom

Abstract

Key Points Fev is required for endothelium-based HSC emergence. Fev directly regulates ERK signaling to regulate HSC development cell-autonomously.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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