B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ-Reference-Cited by-同舟云学术

B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ

Published:2013-04-18 Issue:16 Volume:121 Page:3112-3116
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Salzer Elisabeth¹,Santos-Valente Elisangela¹,Klaver Stefanie¹²,Ban Sol A.¹,Emminger Wolfgang³,Prengemann Nina Kathrin¹,Garncarz Wojciech¹,Müllauer Leonhard⁴,Kain Renate⁴,Boztug Heidrun⁵,Heitger Andreas⁵,Arbeiter Klaus³,Eitelberger Franz⁶,Seidel Markus G.⁵,Holter Wolfgang⁵,Pollak Arnold³,Pickl Winfried F.⁷,Förster-Waldl Elisabeth³,Boztug Kaan¹³

Affiliation:

1. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria;

2. Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil;

3. Department of Pediatrics and Adolescent Medicine,

4. Clinical Institute of Pathology, and

5. Department of Pediatrics, St. Anna Kinderspital and Children’s Cancer Research Institute, Medical University of Vienna, Vienna, Austria;

6. Department of Pediatrics and Adolescent Medicine, Klinikum Wels-Grieskirchen Wels, Austria; and

7. Christian Doppler Laboratory for Immunomodulation and Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

Abstract

Key Points PRKCD deficiency causes a novel primary immunodeficiency with B-cell deficiency and severe autoimmunity. Protein kinase C δ may represent a key factor controlling immune homeostasis and autoimmunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/16/3112/1329909/3112.pdf

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