Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase-Reference-Cited by-同舟云学术

Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase

Published:2013-03-21 Issue:12 Volume:121 Page:2324-2335
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Langer Florian¹,Spath Brigitte¹,Fischer Cornelia¹,Stolz Moritz¹,Ayuk Francis A.²,Kröger Nicolaus²,Bokemeyer Carsten¹,Ruf Wolfram³

Affiliation:

1. II. Medizinische Klinik und Poliklinik and

2. Interdisziplinäre Klinik und Poliklinik für Stammzelltransplantation, Hubertus Wald Tumorzentrum–Universitäres Cancer Center Hamburg, Universitätsklinikum Eppendorf, Hamburg, Germany; and

3. Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA

Abstract

Key PointsATG induces monocyte TF procoagulant activity dependent on complement activation but independent of de novo protein synthesis. TF decryption requires oxidation of cell surface PDI following C5 activation and phosphatidylserine membrane exposure following C7 insertion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/12/2324/1364519/2324.pdf

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