Runx3 deficiency results in myeloproliferative disorder in aged mice

Author:

Wang Chelsia Qiuxia12,Motoda Lena1,Satake Masanobu3,Ito Yoshiaki12,Taniuchi Ichiro4,Tergaonkar Vinay1,Osato Motomi12567

Affiliation:

1. Institute of Molecular and Cell Biology, Singapore;

2. Cancer Science Institute of Singapore, National University of Singapore, Singapore;

3. Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;

4. RIKEN Research Center for Allergy and Immunology, Yokohama, Japan;

5. Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan;

6. School of Biological Sciences, Nanyang Technological University, Singapore; and

7. Institute of Bioengineering and Nanotechnology, Singapore

Abstract

Key Points Runx3 conditional knockout mice develop a myeloproliferative disorder when aged. Runx3-deficient cells show hypersensitivity to G-CSF.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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