CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study

Author:

Hu Shimin1,Xu-Monette Zijun Y.1,Balasubramanyam Aarthi2,Manyam Ganiraju C.3,Visco Carlo4,Tzankov Alexander5,Liu Wei-min2,Miranda Roberto N.1,Zhang Li3,Montes-Moreno Santiago6,Dybkær Karen7,Chiu April8,Orazi Attilio9,Zu Youli10,Bhagat Govind11,Richards Kristy L.12,Hsi Eric D.13,Choi William W. L.14,Han van Krieken J.15,Huang Qin16,Huh Jooryung17,Ai Weiyun18,Ponzoni Maurilio19,Ferreri Andrés J. M.19,Zhao Xiaoying20,Winter Jane N.21,Zhang Mingzhi22,Li Ling22,Møller Michael B.23,Piris Miguel A.6,Li Yong24,Go Ronald S.25,Wu Lin2,Medeiros L. Jeffrey1,Young Ken H.1

Affiliation:

1. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX;

2. Roche Molecular Systems Inc., Pleasanton, CA;

3. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX;

4. San Bortolo Hospital, Vicenza, Italy;

5. University Hospital, Basel, Switzerland;

6. Hospital Universitario Marques de Valdecilla, Santander, Spain;

7. Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark;

8. Memorial Sloan-Kettering Cancer Center, New York, NY;

9. Weill Medical College of Cornell University, New York, NY;

10. The Methodist Hospital, Houston, TX;

11. Columbia University Medical Center and New York Presbyterian Hospital, New York, NY;

12. University of North Carolina School of Medicine, Chapel Hill, NC;

13. Cleveland Clinic, Cleveland, OH;

14. University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, China;

15. Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;

16. City of Hope National Medical Center, Duarte, CA;

17. Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea;

18. University of California San Francisco School of Medicine, San Francisco, CA;

19. San Raffaele H. Scientific Institute, Milan, Italy;

20. Zhejiang University School of Medicine, Second University Hospital, Hangzhou, China;

21. Feinberg School of Medicine, Northwestern University, Chicago, IL;

22. Zhengzhou University Medical Center, Zhengzhou, China;

23. Odense University Hospital, Odense, Denmark;

24. University of Louisville, Louisville, KY; and

25. Gundersen Lutheran Health System, La Crosse, WI

Abstract

Key Points CD30 expression defines a novel and unique subgroup of DLBCL with favorable clinical outcome and distinct gene expression signature.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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