Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients-Reference-Cited by-同舟云学术

Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients

Published:2013-05-23 Issue:21 Volume:121 Page:4366-4376
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gamazon Eric R.¹,Lamba Jatinder K.²,Pounds Stanley³,Stark Amy L.¹,Wheeler Heather E.¹,Cao Xueyuan³,Im Hae K.⁴,Mitra Amit K.²,Rubnitz Jeffrey E.⁵,Ribeiro Raul C.⁵,Raimondi Susana⁶,Campana Dario⁵⁶,Crews Kristine R.⁷,Wong Shan S.¹,Welsh Marleen¹,Hulur Imge¹,Gorsic Lidija¹,Hartford Christine M.⁸,Zhang Wei⁹,Cox Nancy J.¹,Dolan M. Eileen¹

Affiliation:

1. Department of Medicine, The University of Chicago, Chicago, IL;

2. Department of Experimental and Clinical Pharmacology, College of Pharmacy, Pathway driven Pharmacogenomics, University of Minnesota Alliance Institute of Personalized Medicine, University of Minnesota, Minneapolis, MN;

3. Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN;

4. Department of Health Studies, The University of Chicago, Chicago, IL;

5. Department of Oncology,

6. Department of Pathology,

7. Department of Pharmaceutical Sciences, and

8. Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN; and

9. Department of Pediatrics and Institute of Human Genetics, University of Illinois, Chicago, IL

Abstract

Key Points A preclinical cell-based model identifies SNPs associated with cytarabine sensitivity that also associate with outcome in leukemia patients. SNPs within the MCC gene were associated with cytarabine sensitivity in lymphoblastoid cell lines and leukemic blasts from patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/21/4366/1365587/4366.pdf

Reference47 articles.

1. Genetic abnormalities and challenges in the treatment of acute myeloid leukemia.;Kumar;Genes Cancer,2011

2. Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial.;Rubnitz;Lancet Oncol,2010

3. Allogeneic hematopoietic stem cell transplantation for intermediate cytogenetic risk AML in first CR.;Imahashi;Bone Marrow Transplant,2013

4. Curing childhood acute myeloid leukemia (AML) at the half-way point: promises to keep and miles to go before we sleep.;Woods;Pediatr Blood Cancer,2006

5. New strategies for the treatment of acute myeloid leukemia including antibodies and other novel agents.;Tallman;Hematology (Am Soc Hematol Educ Program),2005

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