PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway-Reference-Cited by-同舟云学术

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway

Published:2013-06-27 Issue:26 Volume:121 Page:5208-5217
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kauskot Alexandre¹,Vandenbriele Christophe¹,Louwette Sophie¹,Gijsbers Rik²³,Tousseyn Thomas⁴,Freson Kathleen¹,Verhamme Peter¹,Hoylaerts Marc F.¹

Affiliation:

1. Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences,

2. Leuven Viral Vector Core,

3. Laboratory of Molecular Virology and Gene Therapy, and

4. Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium

Abstract

Key Points PEAR1 is a negative regulator of megakaryocyte proliferation in vitro and thrombocyte formation in vivo. PEAR1 regulates the PI3K/PTEN pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/26/5208/1366981/5208.pdf

Reference45 articles.

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3. Jedi—a novel transmembrane protein expressed in early hematopoietic cells.;Krivtsov;J Cell Biochem,2007

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5. Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation.;Freson;Blood,2001

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