Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia-Reference-Cited by-同舟云学术

Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia

Published:2013-02-28 Issue:9 Volume:121 Page:1663-1672
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Solomon Steven B.¹,Wang Dong¹,Sun Junfeng¹,Kanias Tamir²,Feng Jing¹,Helms Christine C.³,Solomon Michael A.¹,Alimchandani Meghna⁴,Quezado Martha⁴,Gladwin Mark T.²⁵,Kim-Shapiro Daniel B.³,Klein Harvey G.⁶,Natanson Charles¹

Affiliation:

1. Critical Care Medicine Department, National Institutes of Health (NIH) Clinical Center, Bethesda, MD;

2. Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA;

3. Department of Physics and the Translational Science Center, Wake Forest University, Winston-Salem, NC;

4. Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD;

5. Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; and

6. Department of Transfusion Medicine, NIH Clinical Center, Bethesda, MD

Abstract

Key Points In canine S aureus pneumonia, first randomized blinded trial showing blood transfused at end of storage period increases mortality. Increased in vivo hemolysis, cell-free hemoglobin, pulmonary hypertension, tissue damage, and gas exchange abnormalities each contributed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/9/1663/1369199/zh800913001663.pdf

Reference38 articles.

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4. Harmful effects of transfusion of older stored red blood cells: iron and inflammation.;Hod;Transfusion,2011

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