Influence of KIR gene copy number on natural killer cell education-Reference-Cited by-同舟云学术

Influence of KIR gene copy number on natural killer cell education

Published:2013-06-06 Issue:23 Volume:121 Page:4703-4707
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Béziat Vivien¹,Traherne James A.²,Liu Lisa L.¹,Jayaraman Jyothi²,Enqvist Monika¹,Larsson Stella³,Trowsdale John²,Malmberg Karl-Johan¹⁴⁵

Affiliation:

1. Karolinska Institutet, Stockholm, Sweden;

2. Cambridge Institute for Medical Research, Cambridge, United Kingdom;

3. Department of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden;

4. Institute for Cancer Research, Oslo University Hospital Radiumhospitalet; and

5. Institute of Clinical Medicine, University of Oslo, Norway

Abstract

Key Points KIR gene copy number variation influences NK cell education at the repertoire level due to a linear effect on KIR expression. No effect of KIR gene dose on NK cell education at the single cell level.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/23/4703/1366307/4703.pdf

Reference16 articles.

1. KIR and disease: a model system or system of models?;Khakoo;Immunol Rev,2006

2. Association of activating KIR copy number variation of NK cells with containment of SIV replication in rhesus monkeys.;Hellmann;PLoS Pathog,2011

3. Copy number variation of KIR genes influences HIV-1 control.;Pelak;PLoS Biol,2011

4. Current perspectives of natural killer cell education by MHC class I molecules.;Höglund;Nat Rev Immunol,2010

5. Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression.;Li;PLoS Genet,2008

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