Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo-Reference-Cited by-同舟云学术

Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo

Published:2013-04-04 Issue:14 Volume:121 Page:2796-2803
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McGoldrick Suzanne M.¹²,Bleakley Marie E.¹²,Guerrero Abraham¹,Turtle Cameron J.¹²,Yamamoto Tori N.¹,Pereira Shalini E.¹²,Delaney Colleen S.¹²,Riddell Stanley R.¹²³

Affiliation:

1. Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA;

2. University of Washington, School of Medicine, Seattle, WA; and

3. Institute for Advanced Study, Technical University of Munich, Munich, Germany

Abstract

Key PointsPriming of CMV-specific CD4+ and CD8+ T cells occurs as early as day 42 in patients undergoing UCBT. Lack of CMV control in UCBT patients could be related to low absolute frequency of T cells and lack of in vivo expansion of T cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/14/2796/1365514/2796.pdf

Reference38 articles.

1. Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units.;Verneris;Blood,2009

2. Alternative donors hematopoietic stem cells transplantation for adults with acute myeloid leukemia: umbilical cord blood or haploidentical donors?;Ruggeri;Best Pract Res Clin Haematol.,2010

3. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis.;Eapen;Lancet Oncol,2010

5. Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donors.;Smith;Biol Blood Marrow Transplant,2009

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