Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis-Reference-Cited by-同舟云学术

Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis

Published:2013-02-28 Issue:9 Volume:121 Page:1543-1552
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McIntyre Brendan A. S.¹,Ramos-Mejia Veronica¹,Rampalli Shravanti¹,Mechael Rami¹²,Lee Jong-Hee¹,Alev Cantas³,Sheng Guojun³,Bhatia Mickie¹²

Affiliation:

1. McMaster Stem Cell and Cancer Research Institute, Hamilton, ON;

2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON; and

3. Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Japan

Abstract

Key PointsTransient inhibition of hedgehog signaling augments hematopoiesis in hPSC-derived EBs. Hedgehog inhibition initiates an advancement in the developmental state of hematopoietic cells derived from hPSCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/9/1543/1368631/zh800913001543.pdf

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