Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL-Reference-Cited by-同舟云学术

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

Published:2013-09-19 Issue:12 Volume:122 Page:2093-2103
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McCormack Matthew P.¹²,Shields Benjamin J.¹²,Jackson Jacob T.¹,Nasa Chayanica¹,Shi Wei²³,Slater Nicholas J.⁴,Tremblay Cedric S.⁵,Rabbitts Terence H.⁶,Curtis David J.⁵

Affiliation:

1. Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia;

2. Department of Medical Biology, University of Melbourne, Parkville, Australia;

3. Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia;

4. Faculty of Veterinary Medicine, Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom;

5. Department of Medicine, Monash University Central Clinical School, Prahran, Australia; and

6. Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom

Abstract

Key Points Lyl1 is required for Lmo2-induced T-cell leukemia in mice, whereas Scl is dispensable. LYL1 is required for growth of ETP-ALL cell lines.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/12/2093/1369043/2093.pdf

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